DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data. DeepVariant is a suite of Python/C programs that run on any Unix-like operating system. For convenience the documentation refers to building and running DeepVariant on Google Cloud Platform, but the tools themselves can be built and run on any standard Linux computer, including on-premise machines. Note that DeepVariant currently requires Python 2.7 and does not yet work with Python 3. Pre-built binaries are available at gs://deepvariant/. These are compiled to use SSE4 and AVX instructions, so you'll need a CPU (such as Intel Sandy Bridge) that supports them.